New research commissioned by The Lancet reveals that 45% of cases of dementia could potentially be delayed or reduced, marking a 5% increase from their 2020 findings. The updated study also identified two new risk factors, failing eyesight and elevated LDL cholesterol levels, bringing the total number of risk factors to 14.
The study also indicated that addressing most risk factors in mid-life (18-65) had the greatest impact in delaying or preventing the onset of dementia later in life. In early life (0-18), less education was found to have the greatest impact, while social isolation, air pollution and vision loss were found to have a more significant impact on risk in late life (65+). Demographically, researchers suggested that those in lower- and middle-income countries or those of lower socio-economic status were the most at risk from the 14 identified risk factors, thus having the most to gain from interventions to address them.
Figure adapted from Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission July 31, 2024 https://doi.org/10.1016/S0140-6736(24)01296-0
On the research, ADI’s Director of Research and Publications, Wendy Weidner said:
“This study underscores the critical importance of a life-course approach to risk reduction, with targeted interventions across different stages of life. By identifying and addressing these risk factors early on, particularly in lower resourced settings, we have a profound opportunity to reduce the global impact of dementia. While we have yet to find a cure for dementia, every proactive step in addressing dementia risk can make a world of difference at a personal and societal level, and policymakers have an essential role to play.”
In 2023, ADI published its World Alzheimer Report titled “Reducing Dementia Risk: Never Too Early, Never Too Late.” The report provides practical and tangible examples of dementia risk reduction from around the globe. Case studies within the report also grant valuable insights for individuals seeking to modify their own risk and for policymakers aiming to address population-wide risks, offering clear examples of successful interventions worldwide.
